Exploring the ATP-binding site of P2X receptors
نویسندگان
چکیده
منابع مشابه
Exploring the ATP-binding site of P2X receptors
P2X receptors are ATP-gated non-selective cation channels involved in many different physiological processes, such as synaptic transmission, inflammation, and neuropathic pain. They form homo- or heterotrimeric complexes and contain three ATP-binding sites in their extracellular domain. The recent determination of X-ray structures of a P2X receptor solved in two states, a resting closed state a...
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ATP-gated P2X receptors are widely expressed in the nervous system, but their physiological roles are not fully understood. New insights from Pougnet et al. (2014) in this issue of Neuron show that postsynaptic P2X receptors may be activated by ATP released from astrocytes and function to downregulate synaptic AMPA receptors in hippocampal neurons.
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Extracellular adenosine 5' triphosphate (ATP) is a widespread cell-to-cell signaling molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors define a protein family unlike other neurotransmitter-gated ion channels in terms of sequence, subunit topology, assembly, and architecture. Within milliseconds of binding ATP, they catalyze the opening of a cation-selec...
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P2X receptors for extracellular ATP are a distinct family of ligand-gated cation channels involved in physiological processes ranging from synaptic transmission to muscle contraction. Common ATP binding motifs are absent from P2X receptors, and the extent of the agonist binding site is unclear. We used cysteine-scanning mutagenesis, radiolabeled 2-azido ATP binding, and methanethiosulfonate (MT...
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Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its abundance and restriction of passive diffusion across biological membranes. A striking role is the emergence of ATP as a bona fide transmitter molecule, whereby the movement of ATP across membranes serves as a chemical message through a dir...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2013
ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00273